Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by the St. Petersburg Institute of Bioregulation and Gerontology under the direction of Professor Vladimir Khavinson. It belongs to a class of short peptide bioregulators designed to target specific tissue types. Pinealon is the synthetic analog of Epithalamin and is designed to support central nervous system function and pineal gland activity.

Pinealon is proposed to penetrate cell membranes and interact directly with DNA, modulating gene expression in neural tissues. Research suggests it promotes melatonin synthesis in pinealocytes, enhances antioxidant enzyme expression in CNS tissues, and may regulate circadian rhythm-related gene networks. As a bioregulator, it is theorized to restore optimal peptide signaling that declines with aging in the central nervous system.

• Demonstrated neuroprotective effects against oxidative stress in cortical neuron cultures (Khavinson et al., 2011)
• Restored melatonin production in aged pineal gland tissue explants
• Improved cognitive function parameters in aged rat behavioral models
• Enhanced antioxidant defense (SOD, catalase) in brain tissue homogenates
• Showed ability to penetrate nuclear membranes and interact with gene promoter regions in vitro

1. Short peptides regulate gene expression and promote neuroprotection
   Bull Exp Biol Med, 2011
2. Peptide bioregulators of aging and age-related pathology
   Adv Gerontol, 2013
3. Neuroprotective effects of pinealon in oxidative stress models
   Dokl Biol Sci, 2012

Available for Research

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