TB-500, the synthetic version of the naturally occurring peptide Thymosin Beta-4 (Tβ4), is a 43-amino acid peptide that plays a fundamental role in tissue development and repair. Tβ4 is found in virtually all mammalian cells and is particularly concentrated in blood platelets and wound fluid. It is one of the most studied peptides in regenerative medicine research, with a substantial body of preclinical literature.

TB-500's primary mechanism involves sequestration of G-actin monomers, promoting actin polymerization and cell migration. It upregulates the actin-binding protein Arp2/3, which is critical for cell movement and wound healing. Research also shows TB-500 promotes angiogenesis through VEGF pathway modulation, reduces inflammation via NF-κB pathway regulation, and may promote hair follicle stem cell migration.

• Improved cardiac function and reduced scar size in mouse myocardial infarction models (Bock-Marquette et al., 2004)
• Enhanced dermal wound healing with accelerated re-epithelialization and collagen deposition
• Promoted corneal wound healing and reduced inflammatory scarring in ocular models
• Demonstrated anti-inflammatory effects in models of systemic inflammation
• Enhanced neuronal survival and axonal regeneration in CNS injury models

1. Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration
   Nature, 2004
2. Thymosin beta 4 promotes dermal healing
   Ann N Y Acad Sci, 2007
3. Tβ4 promotes angiogenesis, cardiomyocyte survival, and cardiac repair
   Vitam Horm, 2011

Available for Research

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